Cover photograph (Copyright © 2008, American Society for Microbiology. All Rights Reserved.): Uropathogenic Escherichia coli (UPEC) causes a more robust infection in diabetic mice than in healthy mice. Scanning electron microscopy reveals clumps of UPEC (yellow) adhering to the bladder surface in a diabetic mouse at 1-day postinfection. The membranes of bladder superficial umbrella cells form invaginations around the bacteria. (Related paper is on p. 4290.)