This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tizard, I. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tizard, I. R.

 Previous Article  |  Next Article 

Infect Immun. 1971 March; 3(3): 472-477
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Macrophage Cytophilic Antibody in Mice: Effect of Bacterial Lipopolysaccharide on the Uptake of Immunoglobulins by Mouse Peritoneal Cells

Ian R. Tizard1

a Immunology Division, Department of Pathology, University of Cambridge, Cambridge, England

ABSTRACT

Injection of lipopolysaccharide from Escherichia coli intravenously into mice affected the ability of their peritoneal macrophages to adsorb antisheep erythrocyte cytophilic antibodies in vitro. After a single intravenous injection of lipopolysaccharide, the alteration in antibody uptake took the form of a triphasic response. An early evanescent increase in adsorptive capacity took place, which reached a maximum 5 min after injection and was followed immediately by a phase of depressed uptake of antibody. Enhancement of antibody uptake then increased to reach a maximum about 24 hr after injection, before declining slowly. The second enhancement phase was inhibited by prior immunization with E. coli or after multiple injections of lipopolysaccharide. Exposure of macrophages to lipopolysaccharide in vitro did not alter their capacity to take up cytophilic antibody. Changes in the capacity of macrophages and polymorphonuclear neutrophil leukocytes to adsorb opsonized erythrocytes were induced by injection of lipopolysaccharide and were similar to those induced with respect to the uptake of cytophilic antibodies by macrophages.

FOOTNOTES

1 Present address: Department of Veterinary Microbiology and Immunology, University of Guelph, Guelph, Ontario, Canada. Supported by a Wellcome Research Fellowship of the Animal Health Trust and a postdoctoral fellowship from the Medical Research Council of Canada.

Infect Immun. 1971 March; 3(3): 472-477
Copyright © 1971 American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»